1w25

RESPONSE REGULATOR PLED IN COMPLEX WITH C-DI-GMP
Chain A

Phosphorylation site: acidic pocket with Mg++ bound

Substrate binding site: view1

with c-di-GMP bound view2 view3

Note that the ligand is cross-linking to another substrate binding site (belonging to an adjacent dimer, not shown).



About this Structure
1W25 is a Single protein structure of sequence from Caulobacter vibrioides. Full crystallographic information is available from OCA.

Also see C-di-GMP_signaling.

Primary Reference
Structural basis of activity and allosteric control of diguanylate cyclase., Chan C, Paul R, Samoray D, Amiot NC, Giese B, Jenal U, Schirmer T, Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17084-9. Epub 2004 Nov 29. PMID:15569936

Further References
Activated PleD structure 2v0n:

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